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The p53 protein can be divided into three main regions: the amino-terminal transactivation domain, the sequence-specific DNAbinding central core, and the multifunctional carboxy-terminal domain, which includes tetramerization and nuclear localization domains

All the available scientific evidence points in the same direction: that regularly using a water pipe will very likely take a person down the same vicious road of dependence and disease suffered by cigarette smokers. Experts at the Abu Dhabi conference agreed that banning water pipe smoking at this stage would be extremely difficult given its increasing demand, but called for more regulation similar to tobacco smoking

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